Recombinant Human TGF-β3 Protein (HEK293) is a multifunctional cytokine that regulates cell proliferation, growth, differentiation and movement, as well as the synthesis and deposition of extracellular matrix. TGF-β3's expression pattern suggests that it plays a regulatory role in certain developmental processes.
Recombinant human TGF-β3 protein contains 375 amino acids and has a predicted molecular weight of 42.1kd.
Determined by the ability of TGF-β3, which can inhibit the proliferation of mouse IL-4 dependent mouse HT-2 cells, its ED50 value is ≤0.1 ng/ml.
Expression host is Human HEK293 cells
Form | Lyophilized powder |
Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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