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Recombinant Human TGF-β1(HEK293)

Cat. No. M9391
Recombinant Human TGF-β1(HEK293) Structure
Size Price Availability Quantity
10ug USD 256  USD320 In stock
20ug USD 384  USD480 In stock
50ug USD 568  USD710 In stock
100ug USD 848  USD1060 In stock
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Quality Control
  • Current batch:
  • Purity ≥95%, Endotoxin <0.1EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human TGF-β1 (HEK293) regulates cell proliferation, growth, differentiation and cells movement. TGFβ is released from degranulating platelets and secreted by all of the major cell types participating in the repair process, including lymphocytes, macrophages, endothelial cells, smooth muscle cells, epithelial cells, and fibroblasts. Mammals express three isoforms of TGFβ designated TGFβI, TGFβ2, and TGFβ3; TGFβ1 is the most abundant isoform in all tissues, and in human platelets it is the only isoform of the peptide. TGFβ1 has immunomodulatory effects. TGFβ1 has profibrogenic effects.

The ED50 is ≤0.1 ng/mL as measured by HT-2 cells.

Product Citations
Customer Product Validations & Biological Datas
Source Recombinant Human TGF-β1 (AbMole)
Method SDS-PAGE analyses
Cell Lines
Incubation Time
Results The purity is > 97 % by SDS-PAGE analyses.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
CAS Number
Purity ≥95%, Endotoxin <0.1EU/ug
Solubility Water
Storage 2-8°C, dry, protect from light, sealed

[1] Kajdaniuk D, et al. Endokrynol Pol. Transforming growth factor β1 (TGFβ1) in physiology and pathology.

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