Free shipping on all orders over $ 500

Recombinant Human S100A11(E.coli )

Cat. No. M21526
Recombinant Human S100A11(E.coli ) Structure
Synonym:

Protein S100-A11; Calgizzarin; Metastatic lymph node gene 70 protein; MLN 70

Size Price Availability Quantity
10ug USD 200  USD200 In stock
50ug USD 510  USD510 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >95%, Endotoxin<1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: E.coli
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test measured less than 0.1 ng/µg (1EU/µg)
Molecular weight: 11.7 KDa
Storage and stability: The freeze-dried protein should be stored at ≤-20°C for one year after receiving. The recombinant protein solution can be stored at 2-8℃ for 2-7 days. The bisector of the recombinant sample was stable at ≤-20°C for 3 months.



Bioactivity: S100A11 is a member of the calcium-binding protein S100 family. Human S100A11 contains two EF hand motifs, 82% of which share the same amino acid sequence as mouse and rat S100A11. It forms a covalent homodimer and a disulfide tetramer under the action of transglutamine. S100A11 is secreted by keratinocytes and can be cross-linked into the keratinocyte envelope of the skin. Dimerization enhances its ability to signal keratinocytes via RAGE, induce EGF family protein production, and induce cell proliferation. Dimerization also causes S100A11 to bind to RAGE on chondrocytes, leading to chondrocyte hypertrophy and catabolism of cartilage matrix. In addition, S100A11 is found in the cytoplasm and is phosphorylated and transferred to the nucleus in response to DNA damage, RELM alpha exposure, or elevated extracellular calcium concentrations. Calcium also promotes the binding of S100A11 to S100B and to annexins A1, A2 and A6. The S100A11-Annexin A2 complexes are recruited to sites of plasma membrane damage where they promote membrane repair of migrating cancer cells. S100A11 is upregulated in various cancers, supporting tumor cell proliferation, invasion and migration. In addition, S100A11 is produced in the ovary and acts on cumulus cells to inhibit oocyte fertilization.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95%, Endotoxin<1 EU/µg
Solubility Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage at -20°C
Related Cytokines Products
Recombinant Human SCARB2 (Mammalian, C-6His)

Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Recombinant Human Scavenger Receptor Class B Member 2 is produced by Mammalian expression system and the target gene encoding Arg27-Thr432 is expressed with a 6His tag at the C-terminus.

Recombinant Human NANS (E.coli, N-6His)

N-Acetylneuraminate Synthase (NANS) is an enzyme that contains one AFP-like domain. NANS is ubiquitous and plays a role in the biosynthetic pathways of sialic acids. Recombinant Human N-Acetylneuraminate Synthase is produced by E.coli expression system and the target gene encoding Met1-Ser359 is expressed with a 6His tag at the N-terminus.

Recombinant Human UBE2V1 (E.coli, C-6His)

Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6, and TRAF2. It mediates transcriptional activation of target genes. UBE2V1 also controls the progress through the cell cycle and differentiation, the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Recombinant Mouse IFN-beta Protein (HEK293)

Interferon-beta (IFN beta) is an extracellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative, and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 3-18 pg/mL.

Recombinant Mouse IL-7 (CHO, His)

Recombinant Mouse IL-7 (Interleukin-7), also known as lymphopoietin 1 and pre-B cell factor, is a hematopoietic growth factor belonging to the IL-7/IL-9 family. It is produced by keratinocytes, dendritic cells, hepatocytes, neurons and epithelial cells. ED50 is < 0.4 ng/ml, measured in a cell proliferation assay using 2E8 cells.

  Catalog
Abmole Inhibitor Catalog




Keywords: Recombinant Human S100A11(E.coli ), Protein S100-A11; Calgizzarin; Metastatic lymph node gene 70 protein; MLN 70 supplier, Cytokines, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.