Species: Human
Expression system: Mammalian
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Apparent molecular weight: 60-90 kDa, reduction conditions
Storage and stability: Storage temperature ≤-70℃, stable storage for 6 months after receiving goods. After opening, store in aseptic condition for 3 months, storage temperature ≤-70℃. Please minimize freeze-thaw cycles.
Bioactivity: Lysosomal Pro-X carboxypeptidase (PRCP) belongs to peptidase S28 family. PRCP has been detected in many tissues, with the highest levels in placenta, lung, and liver. It is also found in the heart, brain, pancreas and kidneys. PRCP exists as a homodimer. PRCP cleats C-terminal amino acids linked to proline in peptides such as angiotensin II, III, and DES-Arg9-bradykinin. This cleavage occurs at acidic pH, but some substrates remain enzymatic active at neutral pH. PRCP has been shown to be an activator of cell-matrix associated prekallikrein.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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