Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and mice. Because IL-17 has the same properties as IL-1 and tnf-α, it may cause joint inflammation and bone and cartilage destruction. This cytokine is present in the synovial fluid of patients with rheumatoid arthritis and is produced by the synovial membrane of rheumatoid arthritis. It increases IL-6 production, induces collagen degradation, reduces collagen synthesis in synovium and cartilage, and proteoglycan synthesis in cartilage. IL-17 also increases bone destruction and reduces its formation. Blocking interleukin-17 with specific inhibitors provides protective inhibition of cartilage and bone degradation.
Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells, the ED50 for this effect is 1-7 ng/ml.
Accession Q16552
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 16 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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