Recombinant Human IGF-1 LR3 Protein (HEK293) is a mitogenic polypeptide growth factor that can stimulate the proliferation and survival of various cells, including muscle, bone and cartilage tissue. Recombinant Human IGF-1 LR3 is a recombinant analog of human IGF-I and consists of the complete IGF-I sequence , The third glutamic acid is replaced by arginine, and the N-terminal peptide extends 13 amino acids. The isolated IGF-ILR 3 designed for higher biological efficacy has an increased half-life and an aversion to the binding of natural proteins in the body, making it an ideal choice for research and large-scale cultivation.
Recombinant human IGF-1 LR 3 contains 89 amino acids and has a predicted molecular weight of 9.9kd.
The activity of FDC-P1 cell proliferation analysis for ED50 is ≤2.0 ng/ml, and its specific activity is ≥5×105 IU/mg.
Expression host is Human HEK293 cells
| Solubility (25°C) | Water Saline PBS |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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