Species: Human
Expression system: E. coli
Purity: SDS-PAGE analysis > 96%, HPLC analysis > 96%
Endotoxin: LAL protein content < 1 EU/μg
Theoretical molecular weight: 19.5 kDa
Storage and stability: Upon receipt, this product remains stable at -70°C or -20°C for up to 6 months. After reconstruction, the product should be stable at 4°C for up to 1 week or at -20°C for up to 3 months. Avoid repeated freeze-thaw cycles
At least 23 different variants of interferon are known. Individual proteins have a molecular mass of 19-26 kDa and are composed of 156-166 and 172 amino acids. All ifn-α isoforms share a common conserved sequence region between amino acid positions 115-151, and the amino acid terminal terminal is variable. The sequences of many ifn-α isoforms differ in only one or two locations. Naturally occurring variations also include proteins that have 10 amino acids truncated at the carboxyl terminus.
| Solubility (25°C) | Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Wang-Long Chuang, et al. Intervirology. Treatment of chronic hepatitis C in southern Taiwan
[4] H S Panitch. Mult Scler. Early treatment trials with interferon beta in multiple sclerosis
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