GAD67 (GAD1) is a member of thegroup II decarboxylase family. GAD67 is expressed in benign and malignant prostatic tissue and may serve as a highly prostate-specific tissue biomarker. In plants, as in most eukaryotes, glutamate decarboxylase catalyses the synthesis of GABA. Root-specific calcium/calmodulin-regulated GAD67 plays a major role in GABA synthesis in plants under normal growth conditions and in response to stress.
The recombinant human GAD67/GAD1 consists of 605 amino acids and predicts a molecular mass of 68.3 kDa. A DNA sequence encoding the human GAD1 (Met 1-Leu 594) was fused with a polyhistidine tag at the C-terminus.
Accession: Q99259-1
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 64 kDa, reducing conditions
Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% gly, pH 8.5.
Form | Lyophilized powder |
Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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