Genus: Human
Expression system: E.coli
Purity: >96% by SDS-PAGE and HPLC analysis
Endotoxin: rHuCTACK/CCL27 is less than 0.1EU/µg as determined by LAL method
Molecular weight: about 10.1 kDa, a non-glycosylated polypeptide chain containing 88 amino acids
Storage and stability: Use a manually defrosted refrigerator and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C, supplied as is. 1 month, reconstituted at 2 to 8 °C under sterile conditions. 3 months, reconstituted at -20 to -70 °C under sterile conditions.
Bioactivity: Fully bioactive compared to standard. Bioactivity was determined by chemotaxis bioassay using CCR10 transfected BaF3 cells in the concentration range of 10-100 ng/ml.
| Solubility (25°C) | Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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