Species: Human
Expression system: Mammalian
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test less than 0.1 ng/µg (1 EU/µg)
Molecular weight: 12.79 KDa
Storage and stability: The freeze-dried protein should be stored at ≤-20℃ and stored stably for one year after receiving. The recombinant protein solution can be stored at 2-8℃ for 2-7 days. The recombinant samples were stable for 3 months at ≤-20°C.
Bioactivity: t cell surface glycoprotein CD3ε Chain is a single channel type I membrane protein. CD3ε contains one immunoglobulin-like domain and one ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on human chromosome 11. T cell receptor -CD3 complex (TCR/CD3 complex) is involved in T cell development and several intracellular signal transduction pathways. This complex is essential for t cell development and function and is one of the most complex transmembrane receptors. T cell receptor - cd3 complexes have 10 tyrosine-based cytoplasmic immune receptor activation primitives (ITAMs). The TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal transduction pathways.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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