Species: Human
Expression system: E.coli
Purity: > 90% as determined by SDS-PAGE
Predicted molecular weight: 25.81 kDa
Storage and stability: Use manual defrosting freezers to avoid repeated freeze-thaw cycles. Store at 2-8 °C for one week. Store at -20 to -80°C for 12 months from the date of receipt.
Biological activity: Mercaptan protease is involved in bone resorption in osteoclasts and may be partially involved in bone remodeling disorders. Showed strong protease activity against fibrinogen at acidic ph. It may play an important role in the degradation of extracellular matrix. Involved in the release of the thyroid hormone thyroxine (T4) through limited TG/ thyroglobulin proteolysis in the thyroid follicular lumen
| Solubility (25°C) | Reconstitute in sterile water for a stock solution. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] F Bhling, et al. Adv Exp Med Biol. Cathepsin K expression in human lung
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