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Quercetin

Cat. No. M3902
Quercetin Structure
Synonym:

Meletin, Sophoretin

Size Price Availability Quantity
100mg USD 50 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Quercetin significantly down regulates myofibroblast differentiation and fibrotic markers, such as α-smooth muscle actin (α-SMA) and Collagen III (Col III), in both HCFs and HKCs. Collagen III secretion was reduced 80% in both HCFs and HKCs following Quercetin treatment.Furthermore, Quercetin reduced lactate production by HKCs to normal HCF levels. Quercetin down regulated TGF-βR2 and TGF-β2 expression in HKCs suggesting a significant link to the TGF-β pathway. Quercetin is a key regulator of fibrotic markers and ECM assembly by modulating cellular metabolism and TGF-β signaling. Quercetin strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin or the combined use of adenosine diphosphate and thromboxane A(2) inhibitors abrogated platelet spreading on these surfaces to a similar extent. The inhibitory effect of quercetin on platelet kinases blocks early signaling events preventing a complete platelet spreading. PKC inhibitors H-7 and quercetin protect BPAEC from TNF induced injuries and PKC play an important role in EC activation by TNF.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Mice bearing LNCaP xenografts or PC-3 xenografts
Formulation 25% hydroxypropyl-β-cyclodextrin
Dosages 75mg/kg
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 302.24
Formula C15H10O7
CAS Number 117-39-5
Purity >98%
Solubility DMSO 60mg/mL
Storage at -20°C
References

Quercetin attenuates lactate production and extracellular matrix secretion in keratoconus.
McKay TB, et al. Sci Rep. 2015 Mar 11;5:9003. PMID: 25758533.

Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases.
Navarro-Núñez L, et al. Fitoterapia. 2010 Mar;81(2):75-80. PMID: 19686810.

[Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries].
Yu XB, et al. Yao Xue Xue Bao. 1996;31(3):176-81. PMID: 9206266.

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Keywords: Quercetin, Meletin, Sophoretin supplier, PI3K, inhibitors

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