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Protosappanin A dimethyl acetal

Cat. No. M42625
Protosappanin A dimethyl acetal Structure
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Biological Activity

Protosappanin A dimethyl acetal is a homoisoflavonoid.

Chemical Information
Molecular Weight 318.32
Formula C17H18O6
CAS Number 868405-37-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Margareth Duran-Izquierdo et al. BMC Complement Med Ther. Hydroalcoholic extract of Haematoxylum brasiletto protects Caenorhabditis elegans from cadmium-induced toxicity

[2] Mai Thanh Thi Nguyen et al. Chem Pharm Bull (Tokyo). Xanthine oxidase inhibitors from the heartwood of Vietnamese Caesalpinia sappan

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Keywords: Protosappanin A dimethyl acetal supplier, Xanthine Oxidase, inhibitors, activators


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