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Progesterone

Cat. No. M5902
Progesterone Structure
Synonym:

Pregn-4-ene-3,20-dione

Size Price Availability Quantity
100mg USD 40.5  USD45 In stock
500mg USD 54  USD60 In stock
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Quality Control
Biological Activity

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 314.46
Formula C21H30O2
CAS Number 57-83-0
Purity >99%
Solubility 43 mg/mL in Ethanol
Storage at -20°C
References

Effect of different combinations of antibodies and enzyme labels on ELISA of progesterone.
Kumari GL, et al. J Immunoassay Immunochem. 2014;35(2):157-72. PMID: 24295179.

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Keywords: Progesterone, Pregn-4-ene-3,20-dione supplier, Estrogen Receptor, inhibitors

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