Free shipping on all orders over $ 500

Pristane

Cat. No. M11554
Pristane Structure
Synonym:

Norphytane;TMPD

Size Price Availability Quantity
1mL USD 70  USD70 In stock
5mL USD 210  USD210 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Pristane (Norphytane) is a naturally saturated terpene alkane found in small amounts in many plants, various Marine organisms, and is the most active component in mineral oils. Pristane is a non-antigenic adjuvant that induces MHC Class II restrictive arthritis T cells in rats.

Chemical Information
Molecular Weight 268.52
Formula C19H40
CAS Number 1921-70-6
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dattatrya Shetti, et al. Methods Cell Biol. Pristane-induced mammary carcinomas

[2] Xiaowei Li, et al. Exp Cell Res. Pristane promotes anaerobic glycolysis to facilitate proinflammatory activation of macrophages and development of arthritis

[3] Gantsetseg Tumurkhuu, et al. Front Immunol. Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

[4] Dan Li, et al. Arthritis Res Ther. Baicalein ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in myeloid-derived suppressor cells

[5] Eduarda Correa Freitas, et al. Clin Rheumatol. Pristane-induced lupus: considerations on this experimental model

Related Animal Modeling Products
Astragalus Polysacharin (70%)

Astragalus Polysacharin is a natural product from Astragalus membranaeus, used as adjuvant, attenuates TNF-α-induced insulin resistance by suppressing miR-721 and activating PPAR-γ and PI3K/Akt in 3T3-L1 adipocytes.

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin.

PLP (139-151)

PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE).

G6PI 325-339 (human)

G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice.

Heparin sodium salt (MW 15kDa)

Heparin sodium salt (MW 15kDa) is a heparin polymer with a molecular weight of 15kDa.Heparin sodium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII), thereby accelerating the rate of inactivation of Thrombin factor IIa and factor Xa by ATIII. Heparin sodium salt is used for blood collection and plasma preparation in experimental animals and for the construction of parenteral nutrition models in mice.

  Catalog
Abmole Inhibitor Catalog




Keywords: Pristane, Norphytane;TMPD supplier, Animal Modeling, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.