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PF-9366

Cat. No. M9788
PF-9366 Structure
Synonym:

PF9366

Size Price Availability
10mg USD 225 4-7 Days
25mg USD 455 4-7 Days
50mg USD 810 4-7 Days
100mg USD 1365 4-7 Days
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Quality Control
  • Current batch:
  • Purity >97%
  • COA
  • MSDS
Biological Activity

PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), with IC50 of 420 nM and Kd of 170 nM. PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC50 of 1.2 μM in H520 lung carcinoma cells. PF-9366 is more potent in Huh-7 cells against SAM synthesis, with an IC50 of 255 nM, and also suppresses the proliferation of cells with an IC50 of 10 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 350.84
Formula C20H19ClN4
CAS Number 72882-78-1
Purity >97%
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
References

Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A
Casey L Quinlan, et al. Nat Chem Biol. 2017 Jul;13(7):785-792. PMID: 28553945.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PF-9366, PF9366 supplier, inhibitors

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