All AbMole products are for research use only, cannot be used for human consumption.
For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.
PF 04991532 is a potent hepatoselective glucokinase activator (EC50 = 90 nM). Exhibits >50-fold liver to pancreas ratio of tissue distribution. Reduces fasting and postprandial glucose levels with no hypoglycemia in a rat diabetes model.
| Molecular Weight | 396.36 |
| Formula | C18H19F3N4O3 |
| CAS Number | 1215197-37-7 |
| Solubility (25°C) | DMSO 39.64 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Wright, et al. Neuron. The lipid kinase PIP5K1C regulates pain signaling and sensitization.
| Related Glucokinase (GK) Products |
|---|
| AZD1092
AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM. |
| GKM-001
GKM-001 is a glucokinase (GK) activator that can be used in studies related to type 2 diabetes. |
| TMG-123
TMG-123 is a glucokinase (GK) activator that can be used in studies related to type 2 diabetes. |
| PB-201
PB-201 is a glucokinase activator (GKA) that can be used in studies related to type 2 diabetes. |
| MK-0941 free base
MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
