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Peripheral Myelin P0 Protein (180-199), mouse

Cat. No. M13445
Peripheral Myelin P0 Protein (180-199), mouse  Structure
Size Price Availability Quantity
5mg USD 88  USD88 In stock
10mg USD 147  USD147 In stock
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Quality Control & Documentation
Biological Activity

Peripheral Myelin P0 Protein (180-199), mouse is a neurogenic peptide purified from Peripheral Myelin of mice.

Sequence:Ser-Ser-Lys-Arg-Gly-Arg-Gln-Thr-Pro-Val-Leu-Tyr-Ala-Met-Leu-Asp-His-Ser-Arg-Ser

Chemical Information
Molecular Weight 2289.61
Formula C96H161N33O30S
CAS Number 147450-30-4
Solubility (25°C) DMSO : 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chunrong Li, et al. J Clin Neurosci. The therapeutic effects of ginkgolides in Guillain-Barré syndrome and experimental autoimmune neuritis

[2] David G Gonsalvez, et al. Methods Mol Biol. Myelin Protein Zero 180-199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice

[3] Rui-Sheng Duan, et al. Neurobiol Dis. CCR5 deficiency does not prevent P0 peptide 180-199 immunized mice from experimental autoimmune neuritis

[4] Katsuichi Miyamoto, et al. Eur J Immunol. Heterozygous null mutation of myelin P0 protein enhances susceptibility to autoimmune neuritis targeting P0 peptide

[5] L P Zou, et al. J Neurosci Res. P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice

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