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Patentiflorin A 

Cat. No. M30708
Patentiflorin A  Structure
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Biological Activity

Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains.

Chemical Information
Molecular Weight 526.49
Formula C27H26O11
CAS Number 857050-63-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Diptimayee Das, et al. Med Hypotheses. Can plant-derived anti-HIV compounds be used in COVID-19 cases?

[2] František Zálešák, et al. Pharmacol Res. Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances

[3] Subhajit Makar, et al. Eur J Med Chem. Naphthalene, a versatile platform in medicinal chemistry: Sky-high perspective

[4] Hong-Jie Zhang, et al. J Nat Prod. Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa

[5] Sophie Susplugas, et al. J Nat Prod. Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora

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Keywords: Patentiflorin A  supplier, HIV Protease, inhibitors, activators


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