Palmostatin B

Cat. No. M42580

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Quality Control & Documentation

Purity:
COA
MSDS

Product Information

Biological Activity

Palmostatin B is an Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitor.

Chemical Information

Molecular Weight	376.53
Formula	C23H36O4
CAS Number	1233365-12-2
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B K_m
	Animal A K_m

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kim Dore et al. Cell Rep. PSD-95 protects synapses from β-amyloid

[2] Marion Rusch et al. Angew Chem Int Ed Engl. Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M

[3] Jinchao Zhang et al. J Biol Chem. Dynamic cycling of t-SNARE acylation regulates platelet exocytosis

[4] Ying Liu et al. Autophagy. Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1

[5] Igor Vujic et al. Oncotarget. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells

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Signaling Pathways

Palmostatin B

Quality Control & Documentation

Biological Activity

Chemical Information

Conversion of different model animals based on BSA (PMID: 27057123)

References

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