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Oxypeucedanin hydrate

Cat. No. M16269
Oxypeucedanin hydrate Structure
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Biological Activity

Oxypeucedanin hydrate

Chemical Information
CAS Number 133164-11-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ewelina Kozioł, et al. Int J Mol Sci. Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish

[2] Alice Nguvoko Kiyonga, et al. Molecules. Facile and Rapid Isolation of Oxypeucedanin Hydrate and Byakangelicin from Angelica dahurica by Using [Bmim]Tf 2 N Ionic Liquid

[3] Baimei Shi, et al. J Sep Sci. Effect of co-administration of Acori Tatarinowii Rhizoma volatile oil on pharmacokinetic fate of xanthotoxol, oxypeucedanin hydrate, and byakangelicin from Angelicae Dahuricae Radix in rat

[4] Javad Mottaghipisheh, et al. Pharm Biol. Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia

[5] Ying Xie, et al. J Pharm Biomed Anal. High-performance liquid chromatographic method for the determination and pharmacokinetic study of oxypeucedanin hydrate and byak-angelicin after oral administration of Angelica dahurica extracts in mongrel dog plasma

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