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OTX008

Cat. No. M14088
OTX008 Structure
Synonym:

Calixarene 0118; PTX008

Size Price Availability
5mg USD 190  USD190 4-7 Days
10mg USD 290  USD290 4-7 Days
25mg USD 590  USD590 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

OTX008 is a selective inhibitor of galectin-1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 937.18
Formula
CAS Number 286936-40-1
Purity >99%
Solubility Ethanol ≥ 33.33 mg/mL
Storage at -20°C
References

[1] Laetitia Gheysen, et al. New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer

[2] Ahmed M Abu El-Asrar, et al. Galectin-1 studies in proliferative diabetic retinopathy

[3] Nathan A Koonce, et al. Galectin-1 Inhibitor OTX008 Induces Tumor Vessel Normalization and Tumor Growth Inhibition in Human Head and Neck Squamous Cell Carcinoma Models

[4] Lucile Astorgues-Xerri, et al. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis

[5] Massimo Zucchetti, et al. Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib

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Keywords: OTX008, Calixarene 0118; PTX008 supplier, Galectin, inhibitors

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