OTX008 is a selective inhibitor of galectin-1.
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Molecular Weight | 937.18 |
Formula | |
CAS Number | 286936-40-1 |
Purity | >99% |
Solubility | Ethanol ≥ 33.33 mg/mL |
Storage | at -20°C |
[1] Laetitia Gheysen, et al. New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer
[2] Ahmed M Abu El-Asrar, et al. Galectin-1 studies in proliferative diabetic retinopathy
Related Galectin Products |
---|
GB1107
GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.