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NVP-DPP-728 dihydrochloride

Cat. No. M9575
NVP-DPP-728 dihydrochloride Structure
Synonym:

NVP-728 2HCl

Size Price Availability Quantity
10mg USD 200 In stock
25mg USD 450 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

NVP-DPP-728 dihydrochloride is a potent and selective dipeptidyl peptidase IV inhibitor. NVP-DPP-728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. NVP-DPP-728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 371.27
Formula C15H18N6O.2HCl
CAS Number 247016-69-9
Purity >99%
Solubility Water ≥ 40 mg/mL
Storage 2-8°C, dry, sealed
References

Dipeptidyl Peptidase IV Inhibitor NVP-DPP728 Ameliorates Early Insulin Response and Glucose Tolerance in Aged Rats but Not in Aged Fischer 344 Rats Lacking Its Enzyme Activity
Hironobu Mitani, et al. Jpn J Pharmacol. 2002 Apr;88(4):451-8. PMID: 12046989.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: NVP-DPP-728 dihydrochloride, NVP-728 2HCl supplier, DPP-4, inhibitors

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