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Nudifloside C

Cat. No. M16867
Nudifloside C Structure
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Quality Control & Documentation
Biological Activity

Nudifloside C

Chemical Information
CAS Number 297740-99-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qiangqiang Jia, et al. Chem Biodivers. Chemical profiling and quality evaluation of Callicarpa nudiflora from different regions in China by UPLC-QTOF-MS fingerprint

[2] Bo Yi, et al. Zhongguo Zhong Yao Za Zhi. [Analysis of constituents from different parts of Callicarpa nudiflora by UPLC-Q-TOF-MS/MS]

[3] Jun Shao, et al. Pharmacogn Mag. Simultaneous determination of four active components in rat plasma by ultra-high performance liquid chromatography tandem-mass spectrometry/mass spectrometry and its application to a pharmacokinetic study after oral administration of Callicarpa nudiflora 䲧盷Ỵ相

[4] Yan-Chun Ma, et al. Zhongguo Zhong Yao Za Zhi. [Chemical constituents from Callicarpa nudiflora and their cytotoxic activities]

[5] Stephen Hanessian, et al. Org Lett. Synthesis and stereochemical confirmation of the secoiridoid glucosides nudiflosides D and A

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