Free shipping on all orders over $ 500

Nelfinavir Mesylate

Cat. No. M3654

Nelfinavir Mesylate Structure

Synonym: AG-1341

Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 110 In stock
50mg USD 380 In stock
100mg USD 520 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Nelfinavir Mesylate (also known as AG1343) is a potent enzyme inhibitor (Ki = 2 nM) and antiviral agent (HIV-1 ED50 = 14 nM). Nelfinavir (AG1343) is well absorbed orally in a variety of species and possesses favorable pharmacokinetic properties in humans. AG1343 (Viracept) has recently been approved for marketing for the treatment of AIDS.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 663.89
Formula C33H49N3O7S2
CAS Number 159989-65-8
Purity >99%
Solubility DMSO
Storage at -20°C
References

Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.
Kaldor SW, et al. J Med Chem. 1997 Nov 21;40(24):3979-85. PMID: 9397180.

Related HIV Protease Products
Darunavir

Darunavir is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

Saquinavir Mesylate

Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.

Saquinavir

Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.

Atazanavir

Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

Dolutegravir sodium

Dolutegravir sodium is a potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nelfinavir Mesylate, AG-1341 supplier, HIV Protease, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.