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Nattokinase

Cat. No. M2121
Nattokinase Structure
Size Price Availability Quantity
10mg USD 135  USD150 In stock
50mg USD 360  USD400 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nattokinase is an enzyme extracted and purified from a Japanese food called nattō. Nattokinase is a serine protease of the subtilisin family. It exhibits a strong fibrinolytic activity. A 2009 study showed that nattokinase may be effective in catabolism of toxic amyloid fibrils associated with Alzheimer's Disease, as well as the insulin fibrils associated with diabetes and the prion peptide fibrils associated with prion diseases.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 463.5
Formula C23H28ClN3O5
CAS Number 133876-92-3
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Production of nattokinase by batch and fed-batch culture of Bacillus subtilis.
Cho YH, et al. N Biotechnol. 2010 Sep 30;27(4):341-6. PMID: 20541632.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nattokinase supplier, inhibitors

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