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N-Acetyl-L-arginine

Cat. No. M14356
N-Acetyl-L-arginine Structure
Synonym:

Ac-Arg-OH

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Biological Activity

N-Acetyl-L-arginine (Ac-Arg-OH) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population.

Chemical Information
Molecular Weight 216.24
CAS Number 155-84-0
Solubility (25°C) Water 50 mg/mL
DMSO 14.29 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nam Ah Kim, et al. Enhanced protein aggregation suppressor activity of N-acetyl-l-arginine for agitation-induced aggregation with silicone oil and its impact on innate immune responses

[2] Nam Ah Kim, et al. N-Acetylated-L-arginine (NALA) is an enhanced protein aggregation suppressor under interfacial stresses and elevated temperature for protein liquid formulations

[3] Shu-Yi Liao, et al. l-Arginine supplementation in severe asthma

[4] Liang Sun, et al. Seeking mTORC1 Inhibitors Through Molecular Dynamics Simulation of Arginine Analogs Inhibiting CASTOR1

[5] B S Zhorov, et al. [Theoretical conformational analysis of methylamide N-acetyl-L-arginine]

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Keywords: N-Acetyl-L-arginine, Ac-Arg-OH supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

 
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