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MQAE

Cat. No. M13793
MQAE Structure
Size Price Availability Quantity
25mg USD 32  USD40 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

MQAE is a fluorescent indicator that is quenched via collision with chloride, and is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 326.19
Formula
CAS Number 162558-52-3
Purity >99%
Solubility Water 90 mg/mL
DMSO ≥ 35 mg/mL
Storage 2-8°C, protect from light, dry, sealed
References

[1] Sang-Hyun Park, et al. Anal Chem. Mitochondrial Cl --Selective Fluorescent Probe for Biological Applications

[2] Yukiko Ikeuchi, et al. J Physiol Sci. Measurement of [Cl -] i unaffected by the cell volume change using MQAE-based two-photon microscopy in airway ciliary cells of mice

[3] Yury Kovalchuk, et al. Cold Spring Harb Protoc. Two-photon chloride imaging using MQAE in vitro and in vivo

[4] Verena Keitel, et al. Dig Dis. TGR5 in the biliary tree

[5] Charlotte Andersson, et al. Microsc Res Tech. Determination of chloride efflux by X-ray microanalysis versus MQAE-fluorescence

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