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ML SA1

Cat. No. M6983
ML SA1 Structure
Size Price Availability Quantity
10mg USD 85  USD85 In stock
25mg USD 175  USD175 In stock
50mg USD 290  USD290 In stock
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Quality Control & Documentation
Biological Activity

ML SA1 is a activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.

Chemical Information
Molecular Weight 362.42
Formula C22H22N2O3
CAS Number 332382-54-4
Solubility (25°C) DMSO 5.25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yang Wang, et al. Oxid Med Cell Longev. Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia

[2] Yadav, et al. J Pharmacol Exp Ther. Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo.

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