MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3). MK6-83 appears to be significantly more efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells than on those isolated from TRPML1-/- cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 4 mg/mL|
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV
Cheng-Chang Chen, et al. Nat Commun. 2014 Aug 14;5:4681. PMID: 25119295.
|Related TRP Channel Products|
AC1903 is a specific inhibitor of TRPC5 channel.
Nonivamide (also called pelargonic acid vanillylamide or PAVA) can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.
HC-067047 is a potent, selective inhibitor of hTRPV4.
Capsazepine is a specific vanilloid receptor antagonist; synthetic analog of capsaicin.
|SKF 96365 hydrochloride
SKF 96365 hydrochloride is a tRPC channel blocker; also inhibits store-operated Ca2+ entry.
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