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MK6-83

Cat. No. M10315
MK6-83 Structure
Synonym:

MK683

Size Price Availability Quantity
10mg USD 108  USD108 In stock
25mg USD 220  USD220 In stock
50mg USD 372  USD372 In stock
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Quality Control & Documentation
Biological Activity

MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3). MK6-83 appears to be significantly more efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells than on those isolated from TRPML1-/- cells.

Product Citations
Chemical Information
Molecular Weight 336.46
Formula C16H20N2O2S2
CAS Number 1062271-24-2
Solubility (25°C) DMSO 4 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cheng-Chang Chen, et al. Nat Commun. A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV

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Keywords: MK6-83, MK683 supplier, TRP Channel, inhibitors, activators


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