Mineral oil is an emollient cleanser and demulsifier of dirt trapped in pores, used as adjuvant. Mineral oil is used in cosmetics, pharmaceutical bases; food, and fiber production; as carriers and bases; as a lubricating oil and as a solvent for inks in the printing industry.
Molecular Weight | 23.9979 |
CAS Number | 8042-47-5 |
Storage | RT |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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Schizophyllan
Schizophyllan, a β-D-glucan derived from Schizophyllan, activates Tc cells, NK cells, macrophages, as well as promotes the secretion of various lymphokines such as IL-1, IL-2, IL-3, IFN. It can be used as an immune adjuvant with potential immunomodulatory and antitumor activities. |
Aluminum Phosphate
Aluminum Phosphate is a widely used adjuvant and has been shown to increase the excretion rate of strontium for use in studies related to vaccines and gastrointestinal diseases. |
Peptidoglycan
The peptidoglycan (murein) sacculus is a unique and essential structural element in the cell wall of most bacteria. This product is extracted from Bacillus subtilis. |
QS-21
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18. |
Polygalasaponin XXXI
Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine. |
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