Free shipping on all orders over $ 500

Metoclopramide hydrochloride hydrate

Cat. No. M4942
Metoclopramide hydrochloride hydrate Structure
Synonym:

Metoclopramide monohydrochloride monohydrate

Size Price Availability Quantity
50mg USD 60 In stock
100mg USD 80 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic. Metoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male albino Swiss mice
Formulation saline solution
Dosages 20 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 354.27
Formula C14H25Cl2N3O3
CAS Number 54143-57-6
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Risk of extrapyramidal side effects comparing continuous vs. bolus intravenous metoclopramide administration: a systematic review and meta-analysis of randomised controlled trials.
Cavero-Redondo I, et al. J Clin Nurs. 2015 Dec;24(23-24):3638-46. PMID: 26373874.

Antinociception by metoclopramide, ketamine and their combinations in mice.
Mohammad FK, et al. Pharmacol Rep. 2012;64(2):299-304. PMID: 22661179.

Related Dopamine Receptor Products
Sulpiride

Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.

rac-Rotigotine (Hydrochloride)

rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM.

Promazine HCl

Promazine (hydrochloride) is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia.

Prochlorperazine dimaleate salt

Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.

Pramipexole dihydrochloride

Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Metoclopramide hydrochloride hydrate, Metoclopramide monohydrochloride monohydrate supplier, Dopamine Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.