Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
| Molecular Weight | 104.1 |
| Formula | C4H8O3 |
| CAS Number | 6149-41-3 |
| Form | Liquid |
| Storage | -20°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related PROTAC Linker Products |
|---|
| m-PEG-OH(MW5000)
m-PEG-OH is a PROTAC linker and belongs to the PEG class. It can be used to synthesize PROTAC molecules. |
| tert-butyl 4-(3,3-difluoropiperidin-4-yl)piperazine-1-carboxylate
tert-butyl 4-(3,3-difluoropiperidin-4-yl)piperazine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs. |
| Tert-butyl 4-((1-((benzyloxy)carbonyl)piperidin-4-yl)methyl)piperazine-1-carboxylate
Tert-butyl 4-((1-((benzyloxy)carbonyl)piperidin-4-yl)methyl)piperazine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs. |
| Tert-butyl 4-(piperidin-4-ylmethyl)piperazine-1-carboxylate
Tert-butyl 4-(piperidin-4-ylmethyl)piperazine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs. |
| Lenalidomide-acetylene-Br
Lenalidomide-acetylene-Br is a PROTAC Linker taht makes up HJM-561. |
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