Free shipping on all orders over $ 500

MDK36122

Cat. No. M8896
MDK36122 Structure
Synonym:

H-PGDS Inhibitor I

Size Price Availability Quantity
5mg USD 240 In stock
10mg USD 420 In stock
50mg USD 1050 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

MDK36122 selectively blocks HPGDS (IC50s = 0.7 and 32 nM in enzyme and cellular assays, respectively) with little activity against the related human enzymes L-PGDS, mPGES, COX-1, COX-2, and 5-LOX.

Oral administration of HPGDS inhibitor 1 blocked PGD2 production in the rat spleen; inhibition of PGD2 was inversely correlated with the plasma concentration of HPGDS inhibitor 1 in a time and dose-dependent manner. Spleen PGD2 levels fall as HPGDS inhibitor 1 plasma levels increase over time; PGD2 levels return to baseline levels as HPGDS inhibitor 1 plasma levels decline.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 381.37
Formula C19H19F4N3O
CAS Number 1033836-12-2
Purity >98%
Solubility DMSO
Storage at -20°C
References

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS).
Carron CP, et al. ACS Med Chem Lett. 2010 Feb 2;1(2):59-63. PMID: 24900177.

Related Products
Brevianamide F

Brevianamide F belongs to a class of naturally occurring 2,5-diketopiperazines.

Telotristat ethyl

Telotristat ethyl, also known as LX1606, is an oral serotonin synthesis inhibitor or peripheral tryptophan hydroxylase (TPH) inhibitor.

ML-18

ML18 is Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM).

Acecainide HCl

Acecainide HCl, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide.

Sematilide hydrochloride

Sematilide (CK-1752) hydrochloride is a novel class III antiarrhythmic agent.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MDK36122, H-PGDS Inhibitor I supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.