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MCLA hydrochloride

Cat. No. M13792
MCLA hydrochloride Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

MCLA hydrochloride is a chemiluminescent reagent which can be used to quantify aqueous concentrations of superoxide.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 291.73
Formula
CAS Number 128322-44-1
Purity >99%
Solubility
Storage 2-8°C, dry, sealed
References

[1] Michael J Haas, et al. Int J Cardiol. Angiotensin II receptor one (AT1) mediates dextrose induced endoplasmic reticulum stress and superoxide production in human coronary artery endothelial cells

[2] Michael J Haas, et al. Am J Ther. Beta Blockers Suppress Dextrose-Induced Endoplasmic Reticulum Stress, Oxidative Stress, and Apoptosis in Human Coronary Artery Endothelial Cells

[3] Yong Ma, et al. Luminescence. Study on the generation mechanism of reactive oxygen species on calcium peroxide by chemiluminescence and UV-visible spectra

[4] Keiichi Kuwahara, et al. Cornea. Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro

[5] L Zhang, et al. J Biol Chem. Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria

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