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Malachite Green chloride

Cat. No. M25581
Malachite Green chloride Structure
Synonym:

Pigment Green 18

Size Price Availability Quantity
100mg USD 30  USD30 In stock
500mg USD 45  USD45 In stock
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Quality Control & Documentation
  • Purity: Biological Stain
  • COA
  • MSDS
Biological Activity

Malachite Green (Pigment Green) is a low-cost, highly efficient, cationic triphenylmethane dye with high efficacy for treating fungal, bacterial, and parasitic infections. Malachite green chloride can be generally used in aquaculture and highly effective against fungal infections.

Chemical Information
Molecular Weight 364.91
Formula C23H25ClN2
CAS Number 569-64-2
Form Solid
Solubility (25°C) Very soluble in water
Soluble in ethanol
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nataliya A Gavrilenko, et al. Food Chem. Visual determination of malachite green in sea fish samples

[2] Xinhui Zhou, et al. Crit Rev Anal Chem. Review of Methods for the Detection and Determination of Malachite Green and Leuco-Malachite Green in Aquaculture

[3] Luigi Intorre, et al. J Am Vet Med Assoc. Tolerance of benzalkonium chloride, formalin, malachite green, and potassium permanganate in goldfish and zebrafish

[4] Sandra J Culp, et al. Food Chem Toxicol. Carcinogenicity of malachite green chloride and leucomalachite green in B6C3F1 mice and F344 rats

[5] National Toxicology Program. Natl Toxicol Program Tech Rep Ser. Toxicology and carcinogenesis studies of malachite green chloride and leucomalachite green. (CAS NOS. 569-64-2 and 129-73-7) in F344/N rats and B6C3F1 mice (feed studies)

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