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Loureirin B is a flavonoid isolated from The blood tree of Pterygophyllum SPP. It is an inhibitor of PAI-1 with IC50 value of 26.10 μM. Loureirin B can inhibit the phosphorylation of KATP, ERK and JNK at the same time, showing an anti-diabetes effect.
| Molecular Weight | 316.35 |
| Formula | C18H20O5 |
| CAS Number | 119425-90-0 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Mian Cheng, et al. Loureirin B alleviates cardiac fibrosis by suppressing Pin1/TGF-β1 signaling
[4] Yanting Ding, et al. Loureirin B activates GLP-1R and promotes insulin secretion in Ins-1 cells
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