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Cat. No. M9311
Liraglutide Structure

Victoza, Liraglutida, Liraglutidum, NN-2211

Size Price Availability Quantity
1mg USD 129.6  USD144 In stock
5mg USD 473.4  USD526 In stock
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1. Liraglutide can be used to treat obesity in adults with some related comorbidity. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated Raw264.7 cells.

Cell Experiment
Cell lines human umbilical vein endothelial cell line C11-STH20
Preparation method C11-STH cells are cultured to confluence at 37°C in gelatin-coated Nunclon cell culture dishes in Media-199 supplemented with penicillin/streptomycin, 20% FCS, 20 µg/ml endothelial cell growth factor and 20 µg/ml heparin. C11-STH cells are incubated under serum free conditions with liraglutide (100 nM) or the GLP-1 receptor antagonist exendin (9-39) (100 nM) alone or with 10 ng/ml TNFα for 16 h alone or in combination with liraglutide and/or exendin (9-39). ELISA assays for VCAM-1 and ICAM-1 are performed using conditioned medium from C11-STH cells to determine protein expression levels.
Concentrations 100 nM
Incubation time 16 h
Animal Experiment
Animal models Athymic nude mice
Formulation Saline
Dosages 300 μg/kg/day
Administration s.c.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 3751.26
Formula C172H265N43O51
CAS Number 204656-20-2
Purity >95%
Solubility Water: ≥ 5 mg/mL
Storage -20°C, protect from light, dry, sealed

Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model.
Abdulreda MH, et al. Cell Metab. 2016 Mar 8;23(3):541-6. PMID: 26876561.

Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway.
Wang YG, et al. J Geriatr Cardiol. 2015 Jul;12(4):410-6. PMID: 26346224.

A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model.
Gaspari T, et al. Diab Vasc Dis Res. 2011 Apr;8(2):117-24. PMID: 21562063.

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Keywords: Liraglutide, Victoza, Liraglutida, Liraglutidum, NN-2211 supplier, Glucagon Receptor, inhibitors

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