Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.
| Molecular Weight | 270.8 |
| Formula | C14H22N2O.HCl |
| CAS Number | 73-78-9 |
| Solubility (25°C) | 54 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Animal experimental anesthetics Products |
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| Orthocaine
Orthocaine is a local anesthetic agent. |
| Tolycaine
Tolycaine is an amide local anaesthetic. Tolycaine exhibits good anesthetic effects on mice. |
| Etidocaine hydrochloride
Etidocaine hydrochloride is an amino acidamide that acts as a local anesthetic with fast onset and long-acting properties. |
| Lidocaine N-ethyl bromide
Lidocaine N-ethyl bromide is a blocker of non-membrane-permeable,and Inhibits Acid-Induced Activation of Esophageal Nociceptive C Fiber Neurons. |
| MS-222
Tricaine methanesulfonate (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures. |
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