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Licochalcone C could inhibit α-glucosidase, with IC50s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively. Licochalcone-C is an inhibitor of lipopolysaccharide-interferon-γ inflammation. Licochalcone-C acts by improving antioxidant conditions and regulating inducible nitric oxide synthase expression.
Licochalcone C induces T24 cell apoptosis in a concentration dependent manner. Licochalcone C treatment reduces the levels of the anti-apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells.
| Molecular Weight | 338.4 |
| Formula | C21H22O4 |
| CAS Number | 144506-14-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | 4°C, protect from light |
[5] Zengtao Wang, et al. Concise synthesis of licochalcone C and its regioisomer, licochalcone H
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