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Leuprolide Acetate

Cat. No. M5735
Leuprolide Acetate Structure
Synonym:

Leuprorelin acetate

Size Price Availability Quantity
5mg USD 100 In stock
10mg USD 185 In stock
50mg USD 600 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Leuprolide acetate (Leuprorelin) is a GnRH analog; leuprolide acetate acts as an agonist at pituitary GnRH receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1269.45
Formula C61H88N16O14
CAS Number 74381-53-6
Purity >98%
Solubility 43.4 mg/mL in DMSO
Storage at -20°C
References

Differential mRNA expression profiling in ovarian endometriotic tissue with versus without leuprolide acetate treatment.
Kiba A, et al. J Obstet Gynaecol Res. 2015 Oct;41(10):1598-606. PMID: 26374406.

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  Catalog
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Keywords: Leuprolide Acetate, Leuprorelin acetate supplier, Estrogen Receptor, inhibitors

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