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Leuprolide Acetate

Cat. No. M5735
Leuprolide Acetate Structure
Synonym:

Leuprorelin acetate

Size Price Availability Quantity
10mM*1mL USD 123.3  USD137 In stock
5mg USD 69.3  USD77 In stock
10mg USD 89.1  USD99 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Leuprolide acetate (Leuprorelin) is a GnRH analog; leuprolide acetate acts as an agonist at pituitary GnRH receptors.

Product Citations
Customer Product Validations & Biological Datas
Source Prostate (2021). Figure 5. leuprolide (Abmole Bioscience)
Method Cell invasion assay
Cell Lines THP 1 cells
Concentrations 1000 nM
Incubation Time 72 h
Results Additional inclusion of leuprolide (1000 nM) during the 72h invasion period more significantly increased the invasive ability of THP 1 cells
Source Prostate (2021). Figure 4. leuprolide (Abmole Bioscience)
Method Cell invasion assay
Cell Lines THP 1 cells
Concentrations 1000 nM
Incubation Time 72 h
Results Pretreatment of THP1 cells with leuprolide (1000 nM), but not degarelix, significantly increased the MMP9 activity
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1269.45
Formula C61H88N16O14
CAS Number 74381-53-6
Purity >98%
Solubility 43.4 mg/mL in DMSO
Storage at -20°C
References

Differential mRNA expression profiling in ovarian endometriotic tissue with versus without leuprolide acetate treatment.
Kiba A, et al. J Obstet Gynaecol Res. 2015 Oct;41(10):1598-606. PMID: 26374406.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Leuprolide Acetate, Leuprorelin acetate supplier, Estrogen Receptor, inhibitors

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