Leuprolide acetate is a GnRH analog; leuprolide acetate acts as an agonist at pituitary GnRH receptors.
Prostate. 2021 Sep;81(12):902-912.
Gonadotropin-releasing hormone antagonist associated with lower cardiovascular risk compared with gonadotropin-releasing hormone agonist in prostate cancer: A nationwide cohort and in vitro study
Leuprolide Acetate purchased from AbMole
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Source | Prostate (2021). Figure 5. leuprolide (Abmole Bioscience) |
| Method | Cell invasion assay | |
| Cell Lines | THP 1 cells | |
| Concentrations | 1000 nM | |
| Incubation Time | 72 h | |
| Results | Additional inclusion of leuprolide (1000 nM) during the 72h invasion period more significantly increased the invasive ability of THP 1 cells |
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Source | Prostate (2021). Figure 4. leuprolide (Abmole Bioscience) |
| Method | Cell invasion assay | |
| Cell Lines | THP 1 cells | |
| Concentrations | 1000 nM | |
| Incubation Time | 72 h | |
| Results | Pretreatment of THP1 cells with leuprolide (1000 nM), but not degarelix, significantly increased the MMP9 activity |
| Molecular Weight | 1269.45 |
| Formula | C61H88N16O14 |
| CAS Number | 74381-53-6 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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