L-ascorbic acid 2-phosphate Trisodium (2-phospho-L-ascorbic acid Trisodium) can be used as a medium to supplement the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate Trisodium (2-phospho-L-ascorbic acid trisodium) increases alkaline phosphatase (ALP) activity and runx2A in hASC during osteoblast differentiation Expression. 2-Phospho-L-ascorbic acid (Asc 2-P) acts as an antioxidant and stimulator of hepatocyte growth factor (HGF) production. 2-phospho-L-ascorbic acid is a stable derivative of L-ascorbic acid (AA), which has similar biological characteristics to AA. Multiple biological processes regulated by AA and ASC-2P. When 2-phospho-L-ascorbate was added together with DHT, DKK-1 mRNA expression in DPCs induced by DHT was significantly decreased. Dkk-1 promoter activity was increased by DHT treatment. Dht-induced activation of luciferase activity was significantly inhibited when 2-phospho-L-ascorbate was added with DHT.
| Molecular Weight | 322.05 |
| Formula | C6H6Na3O9P |
| CAS Number | 66170-10-3 |
| Solubility (25°C) | Water ≥ 100 mg/mL DMSO 6 mg/mL |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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