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KS176

Cat. No. M5193
KS176 Structure
Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 150  USD150 In stock
50mg USD 600  USD600 In stock
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Quality Control & Documentation
Biological Activity

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter with IC50 values of 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays, respectively. KS176 displays no inhibitory activity against P-gp or MRP1.

Chemical Information
Molecular Weight 405.4
Formula C22H19N3O5
CAS Number 1253452-78-6
Form Solid
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Pick A, et al. ChemMedChem. Specific inhibitors of the breast cancer resistance protein (BCRP).

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  Catalog
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Keywords: KS176 supplier, BCRP/ABCG2/MXR/ABCP, inhibitors, activators


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