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Kinsenoside

Cat. No. M9604
Kinsenoside Structure
Size Price Availability Quantity
5mg USD 185  USD185 In stock
10mg USD 315  USD315 In stock
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Quality Control & Documentation
Biological Activity

Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects. Kinsenoside rescues the nucleus pulposus cells (NPCs) viability under oxidative stress and protects against apoptosis, senescence and mitochondrial dysfunction in a Nrf2-dependent way.

Chemical Information
Molecular Weight 264.23
Formula C10H16O8
CAS Number 151870-74-5
Solubility (25°C) DMSO
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yanqiu Wang, et al. Aging (Albany NY). Kinsenoside Ameliorates Intervertebral Disc Degeneration Through the Activation of AKT-ERK1/2-Nrf2 Signaling Pathway

[2] Chang-Xing Qi, et al. Curr Med Sci. Kinsenoside: A Promising Bioactive Compound From Anoectochilus Species

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