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Kinase Inhibitor Library

Cat. No. MS1010
Kinase Inhibitor Library Structure
Synonym:

Screening Library Libraries

Size Price Availability
100 μL/well (10mM solution) USD 5984 Custom Synthesis
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Quality Control
Biological Activity

• A unique collection of 544 kinase inhibitors for high throughput screening (HTS) and high content screening (HCS)
• Bioactivity and safety confirmed by preclinical research and clinical trials
• FDA authentication of some inhibitors
• RTKs, PI3K, Aurora Kinase, CDK, and MEK target inbibitors
• Most are ATP competitive
• Structurally diverse, medicinally active, and cell permeable
• Abundant documentation with structure, IC50, and customer reviews
• Quality inspection report of NMR and HPLC ensure high purity

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity 544
Solubility
Storage at -20°C
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FDA-approved Drug Library

A unique collection of 1788 FDA approved drugs for HTS and HCS.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Kinase Inhibitor Library, Screening Library Libraries supplier, Screening Libraries, inhibitors

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