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KIN1148

Cat. No. M9281
KIN1148 Structure
Synonym:

KIN-1148

Size Price Availability Quantity
10mM*1mL In DMSO USD 397 In stock
2mg USD 333 In stock
5mg USD 498 In stock
10mg USD 832 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

KIN1148 induced dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protected against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induced an influenza virus-specific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 361.44
Formula C19H11N3OS2
CAS Number 1428729-56-9
Purity >98%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response.
Probst P, et al. Vaccine. 2017 Apr 4;35(15):1964-1971. PMID: 28279563.

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