Free shipping on all orders over $ 500

KIN1148

Cat. No. M9281
KIN1148 Structure
Synonym:

KIN-1148

Size Price Availability Quantity
10mM*1mL In DMSO USD 397 In stock
1mg USD 167 In stock
2mg USD 333 In stock
5mg USD 497 In stock
10mg USD 830 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

KIN1148 induced dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protected against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induced an influenza virus-specific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 361.44
Formula C19H11N3OS2
CAS Number 1428729-56-9
Purity >98%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response.
Probst P, et al. Vaccine. 2017 Apr 4;35(15):1964-1971. PMID: 28279563.

Related Anti-infection Products
Gramicidin

Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations.

Cefazolin

Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis.

Vancomycin

Vancomycin is an antibiotic for the treatment of bacterial infections.

Nourseothricin sulfate

Nourseothricin is a broad-spectrum antibiotic derived from Streptomyces noursei.

Targocil

Targocil is a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis, with MIC90s of 2 μg/ mL for both MRSA and MSSA.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: KIN1148, KIN-1148 supplier, Anti-infection, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.