Kadsurin A

Cat. No. M41904

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Quality Control & Documentation

Purity:
COA
MSDS

Product Information

Biological Activity

Kadsurin A is a new lignan can be isolated from Piper futokadsura.

Chemical Information

Molecular Weight	372.41
Formula	C21H24O6
CAS Number	99340-07-5
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B K_m
	Animal A K_m

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ming Hong et al. Molecules. A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae

[2] Qian Chen et al. Yao Xue Xue Bao. [Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A]

[3] Yan Lu et al. Nat Prod Res. Kadsutherin D, a new dibenzocyclooctadiene lignan from Kadsura species

[4] L Dupont et al. Pharmacol Res Commun. Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds

[5] X W Yang et al. Chem Pharm Bull (Tokyo). Anti-lipid peroxidative effect of an extract of the stems of Kadsura heteroclita and its major constituent, kadsurin, in mice

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Signaling Pathways

Kadsurin A

Quality Control & Documentation

Biological Activity

Chemical Information

Conversion of different model animals based on BSA (PMID: 27057123)

References

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