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Hydroxyevodiamine

Cat. No. M39051
Hydroxyevodiamine Structure
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Biological Activity

Hydroxyevodiamine (Rhetsinine) inhibits aldose reductase with an IC50 value of 24.1 μM.

Chemical Information
Molecular Weight 319.36
Formula C19H17N3O2
CAS Number 1238-43-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shuqiang Chen et al. Eur J Med Chem. Water-soluble derivatives of evodiamine: Discovery of evodiamine-10-phosphate as an orally active antitumor lead compound

[2] Xiaoxia Liang et al. Future Med Chem. Autophagy-regulating N-heterocycles derivatives as potential anticancer agents

[3] Shuqiang Chen et al. Acta Pharm Sin B. Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

[4] Guozheng Huang et al. Eur J Med Chem. Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine

[5] M Yamazaki et al. Yakugaku Zasshi. [Isolation of hydroxyevodiamine (rhetsinine) from the fruits of Evodia rutaecarpa Hook fil. et Thomson]

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Keywords: Hydroxyevodiamine supplier, Aldose Reductase, inhibitors, activators

 
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