Recombinant Mouse HSP60 Protein (E.coli, His) is a member of the chaperone protein family. HSP60 acts as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. It may also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
A DNA sequence encoding the mouse HSP60 (NP_034607.3) (Leu 2-Phe 573) was expressed, with a polyhistide tag at the N-terminus.
The recombinant mouse HSP60 consisting of 583 amino acids and has a calculated molecular mass of 62.3 kDa. rmHSP60 migrates as an approximately 58 kDa band in SDS-PAGE under reducing conditions.
Lyophilized from sterile PBS, pH 7.4.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. |
| Storage | Stable for up to twelve months from date of receipt at -20℃ to -80℃ |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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