Hemin is an iron-containing porphyrin. Hemin strongly increased both expression and activity of HMOX after 4 and 12 h, respectively. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons.
In vivo, following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules.
Molecular Weight | 651.94 |
Formula | C34H32ClFeN4O4 |
CAS Number | 16009-13-5 |
Solubility (25°C) | 1M NaOH: 6 mg/mL (ultrasonic and adjust pH to 12 with NaOH) DMSO ≥ 6 mg/mL (Need ultrasonic and warming) |
Storage | 4°C, protect from light, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Aliye Uc, et al. Hemin induces active chloride secretion in Caco-2 cells
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