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Hemin chloride

Cat. No. M9092
Hemin chloride Structure
Synonym:

Hemin

Size Price Availability Quantity
500mg USD 60 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Hemin is an iron-containing porphyrin. Hemin strongly increased both expression and activity of HMOX after 4 and 12 h, respectively. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons.

In vivo, following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 651.94
Formula C34H32ClFeN4O4
CAS Number 16009-13-5
Purity >98%
Solubility DMSO: ≥ 6 mg/mL (Need ultrasonic and warming)
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Hemin chloride, Hemin supplier, Autophagy, inhibitors

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